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Importance and impact of phthalates during peritoneal dialysis and current possibilities of their replacement
Nohelová, Gabriela ; Zlámalová Gargošová, Helena (referee) ; Čáslavský, Josef (advisor)
This thesis deals with the importance and influence of phthalates in peritoneal dialysis (PD) and the current possibilities of their replacement. The information about phthalates – esters of phthalic acid - was completed with focus on the most commonly used plasticizer in medical material, bis(2-ethylhexyl) phthalate (DEHP) and its effects on the human organism and the environment. The possibilities of substitution of PVC in peritoneal dialysis were searched and their advantages and disadvantages were evaluated. As the evidence of phthalates absorbed by the human body in carrying out peritoneal dialysis selected studies performed in Germany and in our country, dealing with this issue, were used. High performance liquid chromatography (HPLC) with UV detection at 224 nm or gas chromatography - mass spectrometry (GC / MS) was used here for the determination of phthalates in the blood and dialysate in peritoneal dialysis. Extraction of sample with the suitable solvent and purification of the extract predates the actual analytical determination of sample.
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Importance and impact of phthalates during peritoneal dialysis and current possibilities of their replacement
Nohelová, Gabriela ; Zlámalová Gargošová, Helena (referee) ; Čáslavský, Josef (advisor)
This thesis deals with the importance and influence of phthalates in peritoneal dialysis (PD) and the current possibilities of their replacement. The information about phthalates – esters of phthalic acid - was completed with focus on the most commonly used plasticizer in medical material, bis(2-ethylhexyl) phthalate (DEHP) and its effects on the human organism and the environment. The possibilities of substitution of PVC in peritoneal dialysis were searched and their advantages and disadvantages were evaluated. As the evidence of phthalates absorbed by the human body in carrying out peritoneal dialysis selected studies performed in Germany and in our country, dealing with this issue, were used. High performance liquid chromatography (HPLC) with UV detection at 224 nm or gas chromatography - mass spectrometry (GC / MS) was used here for the determination of phthalates in the blood and dialysate in peritoneal dialysis. Extraction of sample with the suitable solvent and purification of the extract predates the actual analytical determination of sample.
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Hodnocení stavu životního prostředí: Monitoring cizorodých látek v potravních řetězcích: Pilotní studie
Vysoká škola chemicko-technologická v Praze, Praha ; Suchánek, Miloslav ; Hajšlová, Jana ; Volka, Karel
Jsou obsaženy 4 analytické studie: D.7 Zhodnocení incidence environmentálních estrogenů ve Vltavě a Labi ve vztahu k biologickým efektům na biotu - zatížení vodního ekosystému (řeky Vltavy, Labe a Tiché Orlice) persistentními chlorovanými xenobiotiky s estrogenní aktivitou, D.8 Aplikace techniky LC/MS pro sledování vlivu prioritních environmentálních kontaminantů na vybrané složky životního prostředí - popis hmotnostně spektrometrické techniky ve spojení s technikou kapalinové chromatometrie, D.9 Vzorkovací pokus s živými biomarkery - testování možnosti využití krve živé zvěře pro účely biomonitoringu, D.10 Hodnocení zátěže ekosystému estery ftalové kyseliny v blízkosti bodového zdroje - validace analytického postupu pro stanovení esterů ftalové kyseliny v tereristické vegetaci využívající k extrakci metodu SFE, aplikace metody SPME pro analýzu vzorků vod, validace metody pro stanovení ftalátů v půdě, kalech sedimentech využívající metodu ASE, vyšetření složek ekosystému na obsah jednotlivých esterů ftalové kyseliny v okolí potenciálního zdroje znečištění, zhodnocení nálezů ftalátů.
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